Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism
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منابع مشابه
Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism
Neointimal hyperplasia is a product of VSMC replication and consequent accumulation within the blood vessel wall. In this study, we determined whether inhibition of protein kinase CK2 and the resultant stabilisation of proline-rich homeodomain (PRH) could suppress VSMC proliferation. Both silencing and pharmacological inhibition of CK2 with K66 antagonised replication of isolated VSMCs. SiRNA-i...
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CK2, one of the first protein kinase ever discovered, is an eukaryotic acidophilic Ser/Thr protein kinase. CK2 is considered a quite anomalous protein kinase for the following peculiar properties: i) it is highly pleiotropic, ii) it can use both ATP and GTP as co-substrate, iii) the target ser-ine or threonine must be surrounded by acidic residues (with the minimal consensus sequence Ser/Thr-X-...
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Casein kinase 2 (CK2) is a constitutively active serine/threonine kinase that promotes cell proliferation and resists apoptosis. Elevated CK2 expression has been demonstrated in several solid tumors. The expression of CK2α in bladder cancer was elevated in tumor tissues compared with that in adjacent normal tissues. Amplified expression of CK2α was highly correlated with histological grade in b...
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OBJECTIVE Fluid shear stress (flow) modulates endothelial cell (EC) function via specific signal transduction events. Previously, we showed that flow-mediated tyrosine phosphorylation of p130 Crk-associated substrate (Cas) required calcium-dependent c-Src activation. Because flow increases reactive oxygen species (ROS) production in ECs and because H(2)O(2) increases tyrosine phosphorylation of...
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Glomerulonephritis (GN) is a progressive inflammation that may be caused by a variety of underlying disorders. It is the primary cause of chronic renal failure and end-stage renal disease, which require dialysis and transplantation worldwide. Immunosuppressive therapy has been used to treat GN clinically, but this treatment has had insufficient therapeutic effects. Here, we show that protein ki...
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ژورنال
عنوان ژورنال: Vascular Pharmacology
سال: 2017
ISSN: 1537-1891
DOI: 10.1016/j.vph.2017.09.004